Poor concordance between CA-125 and RECIST at the time of disease progression in patients with platinum-resistant ovarian cancer: analysis of the AURELIA trial.
Identifieur interne : 001937 ( Main/Exploration ); précédent : 001936; suivant : 001938Poor concordance between CA-125 and RECIST at the time of disease progression in patients with platinum-resistant ovarian cancer: analysis of the AURELIA trial.
Auteurs : K. Lindemann [Oman] ; G. Kristensen [Norvège] ; M R Mirza [Danemark] ; L. Davies [Australie] ; F. Hilpert [Allemagne] ; I. Romero [Espagne] ; A. Ayhan [Turquie] ; A. Burges [Allemagne] ; M J Rubio [Espagne] ; F. Raspagliesi [Italie] ; M. Huizing [Belgique] ; G-J Creemers [Pays-Bas] ; M. Lykka [Grèce] ; C K Lee [Australie] ; V. Gebski [Australie] ; E. Pujade-Lauraine [France]Source :
- Annals of oncology : official journal of the European Society for Medical Oncology [ 1569-8041 ] ; 2016.
Abstract
Data on CA-125 as a predictor of disease progression (PD) in ovarian cancer come predominantly from patients with platinum-sensitive disease receiving chemotherapy alone. We assessed concordance between CA-125-defined and RECIST-defined PD using data from the Gynecologic Cancer InterGroup (GCIG) randomized phase III AURELIA trial in platinum-resistant ovarian cancer (PROC).
DOI: 10.1093/annonc/mdw238
PubMed: 27407100
Affiliations:
- Allemagne, Australie, Belgique, Danemark, Espagne, France, Grèce, Italie, Norvège, Oman, Pays-Bas, Turquie
- Attique (région), Bavière, District de Haute-Bavière, Hambourg, Hovedstaden, Lombardie, Nouvelle-Galles du Sud, Île-de-France, Østlandet
- Athènes, Copenhague, Hambourg, Milan, Munich, Oslo, Paris, Sydney
- Université Louis-et-Maximilien de Munich, Université de Sydney
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Lindemann</name><affiliation wicri:level="1"><nlm:affiliation>NSGO and Department of Gynecological Cancer, The Norwegian Radium Hospital, Oslo University Hospital, Oslo stinalindemann@hotmail.com.</nlm:affiliation><country wicri:rule="url">Oman</country><wicri:regionArea>NSGO and Department of Gynecological Cancer, The Norwegian Radium Hospital, Oslo University Hospital</wicri:regionArea><wicri:noRegion>Oslo University Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Kristensen, G" sort="Kristensen, G" uniqKey="Kristensen G" first="G" last="Kristensen">G. Kristensen</name><affiliation wicri:level="3"><nlm:affiliation>NSGO and Department of Gynecological Cancer and Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital and Institute for Clinical Medicine, Oslo University, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>NSGO and Department of Gynecological Cancer and Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital and Institute for Clinical Medicine, Oslo University, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Mirza, M R" sort="Mirza, M R" uniqKey="Mirza M" first="M R" last="Mirza">M R Mirza</name><affiliation wicri:level="3"><nlm:affiliation>NSGO and Department of Oncology, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>NSGO and Department of Oncology, Rigshospitalet Copenhagen University Hospital, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Davies, L" sort="Davies, L" uniqKey="Davies L" first="L" last="Davies">L. Davies</name><affiliation wicri:level="4"><nlm:affiliation>NHMRC Clinical Trials Centre, University of Sydney, Camperdown, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>NHMRC Clinical Trials Centre, University of Sydney, Camperdown</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Hilpert, F" sort="Hilpert, F" uniqKey="Hilpert F" first="F" last="Hilpert">F. Hilpert</name><affiliation wicri:level="3"><nlm:affiliation>AGO and Oncological Center, Hospital Jerusalem, Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>AGO and Oncological Center, Hospital Jerusalem, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Romero, I" sort="Romero, I" uniqKey="Romero I" first="I" last="Romero">I. Romero</name><affiliation wicri:level="1"><nlm:affiliation>GEICO and Valencia Institute of Oncology, Valencia, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>GEICO and Valencia Institute of Oncology, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Ayhan, A" sort="Ayhan, A" uniqKey="Ayhan A" first="A" last="Ayhan">A. Ayhan</name><affiliation wicri:level="1"><nlm:affiliation>GINECO and Baskent University, Ankara, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>GINECO and Baskent University, Ankara</wicri:regionArea><wicri:noRegion>Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Burges, A" sort="Burges, A" uniqKey="Burges A" first="A" last="Burges">A. Burges</name><affiliation wicri:level="4"><nlm:affiliation>AGO and Department of Gynecology and Obstetrics, Hospital of University of Munich, Campus Großhadern, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>AGO and Department of Gynecology and Obstetrics, Hospital of University of Munich, Campus Großhadern, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Rubio, M J" sort="Rubio, M J" uniqKey="Rubio M" first="M J" last="Rubio">M J Rubio</name><affiliation wicri:level="1"><nlm:affiliation>GEICO and University Hospital Queen Sofía, Córdoba, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>GEICO and University Hospital Queen Sofía, Córdoba</wicri:regionArea><wicri:noRegion>Córdoba</wicri:noRegion></affiliation></author><author><name sortKey="Raspagliesi, F" sort="Raspagliesi, F" uniqKey="Raspagliesi F" first="F" last="Raspagliesi">F. Raspagliesi</name><affiliation wicri:level="3"><nlm:affiliation>MITO and National Tumour Institute of Milan, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>MITO and National Tumour Institute of Milan, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Huizing, M" sort="Huizing, M" uniqKey="Huizing M" first="M" last="Huizing">M. Huizing</name><affiliation wicri:level="1"><nlm:affiliation>BGOG and Antwerp University Hospital, Edegem, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>BGOG and Antwerp University Hospital, Edegem</wicri:regionArea><wicri:noRegion>Edegem</wicri:noRegion></affiliation></author><author><name sortKey="Creemers, G J" sort="Creemers, G J" uniqKey="Creemers G" first="G-J" last="Creemers">G-J Creemers</name><affiliation wicri:level="1"><nlm:affiliation>DGOG and Catharina Hospital, Eindhoven, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>DGOG and Catharina Hospital, Eindhoven</wicri:regionArea><wicri:noRegion>Eindhoven</wicri:noRegion></affiliation></author><author><name sortKey="Lykka, M" sort="Lykka, M" uniqKey="Lykka M" first="M" last="Lykka">M. Lykka</name><affiliation wicri:level="3"><nlm:affiliation>HECOG and University of Athens, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>HECOG and University of Athens, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Lee, C K" sort="Lee, C K" uniqKey="Lee C" first="C K" last="Lee">C K Lee</name><affiliation wicri:level="4"><nlm:affiliation>NHMRC Clinical Trials Centre, University of Sydney, Camperdown, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>NHMRC Clinical Trials Centre, University of Sydney, Camperdown</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Gebski, V" sort="Gebski, V" uniqKey="Gebski V" first="V" last="Gebski">V. Gebski</name><affiliation wicri:level="4"><nlm:affiliation>NHMRC Clinical Trials Centre, University of Sydney, Camperdown, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>NHMRC Clinical Trials Centre, University of Sydney, Camperdown</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Pujade Lauraine, E" sort="Pujade Lauraine, E" uniqKey="Pujade Lauraine E" first="E" last="Pujade-Lauraine">E. Pujade-Lauraine</name><affiliation wicri:level="3"><nlm:affiliation>GINECO and Paris Descartes University, AP-HP Central Paris University Hospitals, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>GINECO and Paris Descartes University, AP-HP Central Paris University Hospitals, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">Annals of oncology : official journal of the European Society for Medical Oncology</title><idno type="eISSN">1569-8041</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Data on CA-125 as a predictor of disease progression (PD) in ovarian cancer come predominantly from patients with platinum-sensitive disease receiving chemotherapy alone. We assessed concordance between CA-125-defined and RECIST-defined PD using data from the Gynecologic Cancer InterGroup (GCIG) randomized phase III AURELIA trial in platinum-resistant ovarian cancer (PROC).</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Danemark</li><li>Espagne</li><li>France</li><li>Grèce</li><li>Italie</li><li>Norvège</li><li>Oman</li><li>Pays-Bas</li><li>Turquie</li></country><region><li>Attique (région)</li><li>Bavière</li><li>District de Haute-Bavière</li><li>Hambourg</li><li>Hovedstaden</li><li>Lombardie</li><li>Nouvelle-Galles du Sud</li><li>Île-de-France</li><li>Østlandet</li></region><settlement><li>Athènes</li><li>Copenhague</li><li>Hambourg</li><li>Milan</li><li>Munich</li><li>Oslo</li><li>Paris</li><li>Sydney</li></settlement><orgName><li>Université Louis-et-Maximilien de Munich</li><li>Université de Sydney</li></orgName></list><tree><country name="Oman"><noRegion><name sortKey="Lindemann, K" sort="Lindemann, K" uniqKey="Lindemann K" first="K" last="Lindemann">K. Lindemann</name></noRegion></country><country name="Norvège"><region name="Østlandet"><name sortKey="Kristensen, G" sort="Kristensen, G" uniqKey="Kristensen G" first="G" last="Kristensen">G. Kristensen</name></region></country><country name="Danemark"><region name="Hovedstaden"><name sortKey="Mirza, M R" sort="Mirza, M R" uniqKey="Mirza M" first="M R" last="Mirza">M R Mirza</name></region></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Davies, L" sort="Davies, L" uniqKey="Davies L" first="L" last="Davies">L. Davies</name></region><name sortKey="Gebski, V" sort="Gebski, V" uniqKey="Gebski V" first="V" last="Gebski">V. Gebski</name><name sortKey="Lee, C K" sort="Lee, C K" uniqKey="Lee C" first="C K" last="Lee">C K Lee</name></country><country name="Allemagne"><region name="Hambourg"><name sortKey="Hilpert, F" sort="Hilpert, F" uniqKey="Hilpert F" first="F" last="Hilpert">F. Hilpert</name></region><name sortKey="Burges, A" sort="Burges, A" uniqKey="Burges A" first="A" last="Burges">A. Burges</name></country><country name="Espagne"><noRegion><name sortKey="Romero, I" sort="Romero, I" uniqKey="Romero I" first="I" last="Romero">I. Romero</name></noRegion><name sortKey="Rubio, M J" sort="Rubio, M J" uniqKey="Rubio M" first="M J" last="Rubio">M J Rubio</name></country><country name="Turquie"><noRegion><name sortKey="Ayhan, A" sort="Ayhan, A" uniqKey="Ayhan A" first="A" last="Ayhan">A. Ayhan</name></noRegion></country><country name="Italie"><region name="Lombardie"><name sortKey="Raspagliesi, F" sort="Raspagliesi, F" uniqKey="Raspagliesi F" first="F" last="Raspagliesi">F. Raspagliesi</name></region></country><country name="Belgique"><noRegion><name sortKey="Huizing, M" sort="Huizing, M" uniqKey="Huizing M" first="M" last="Huizing">M. Huizing</name></noRegion></country><country name="Pays-Bas"><noRegion><name sortKey="Creemers, G J" sort="Creemers, G J" uniqKey="Creemers G" first="G-J" last="Creemers">G-J Creemers</name></noRegion></country><country name="Grèce"><region name="Attique (région)"><name sortKey="Lykka, M" sort="Lykka, M" uniqKey="Lykka M" first="M" last="Lykka">M. Lykka</name></region></country><country name="France"><region name="Île-de-France"><name sortKey="Pujade Lauraine, E" sort="Pujade Lauraine, E" uniqKey="Pujade Lauraine E" first="E" last="Pujade-Lauraine">E. Pujade-Lauraine</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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